Retinal renin and proliferative retinopathy

Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy.

BACKGROUND Although vascular endothelial growth factor (VEGF) is a primary mediator of retinal angiogenesis, VEGF inhibition alone is insufficient to prevent retinal neovascularization. Hence, it is postulated that there are other potent ischemia-induced angiogenic factors. Erythropoietin possesses angiogenic activity, but its potential role in ocular angiogenesis is not established. METHODS ...

Automated detection of proliferative diabetic retinopathy from retinal images

Small retinal vessels extraction towards proliferative diabetic retinopathy screening

This paper introduces a systematic approach for segmentation of retinal blood vessels towards the diagnosis of proliferative diabetic retinopathy (PDR) from digital fundus images. Here, 2D-Match (Gabor) filters are used on digital fundus images in which the vessels are enhanced by contrast-limited adaptive histogram equalization (CLAHE). A double sided thresholding scheme is then used to segmen...

Osteopontin expression in vitreous and proliferative retinal membranes of patients with proliferative vitreous retinopathy.

AIM To analyze osteopontin (OPN) expression in vitreous and proliferative retinal membranes of patients with proliferative vitreous retinopathy (PVR). METHODS A total of 54 vitreous fluid samples were obtained between 2009 and 2010, which contained 45 with PVR (group A) and 9 without PVR (group B). Enzyme-linked immunosorbent assay was applied to quantify the OPN concentrations in vitreous fl...

Renin-angiotensin system in proliferative diabetic retinopathy and its gene expression in cultured human müller cells.

PURPOSE To determine if the renin-angiotensin system (RAS) is involved in diabetic retinopathy, we measured the levels of angiotensin-converting enzyme (ACE) and angiotensin II in the vitreous of patients with proliferative diabetic retinopathy (PDR). We also investigated whether the genes of the RAS factors were expressed by cultured human Müller cells. METHODS Vitreous samples were collecte...